Russell DeBose-Boyd (UTSW) 1: Feedback Regulation of ...

This enzyme is the target of the widely available cholesterol-lowering drugs known collectively as the statins, which help treat dyslipidemia.

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9 Sept 2025 — HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol ...

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by AB Bansal · 2023 · Cited by 87 — HMG-CoA reductase inhibitors (statins) are lipid-lowering medications used in the primary and secondary prevention of coronary heart disease.

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HMG-CoA reductase is an enzyme that converts HMG-CoA to mevalonate, is rate-limiting in cholesterol biosynthesis, and is a target for statins.

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by BE Haines · 2013 · Cited by 82 — HMG-CoA reductase (HMGR) is the target of statins, cholesterol-lowering drugs prescribed to millions of patients worldwide.

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by DS Gesto · 2020 · Cited by 79 — HMG-CoAR catalyzes a key step in cholesterol biosynthesis and is a major drug target for hypercholesterolemia, with statins being a common inhibitor.

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A substance that blocks an enzyme needed by the body to make cholesterol and lowers the amount of cholesterol in the blood.

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by SY Jiang · 2018 · Cited by 196 — Statins are inhibitors of HMG-CoA reductase, the rate-limiting enzyme of cholesterol biosynthesis, and have been clinically used to treat ...

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The inhibition of HMG-CoA reductase by rosuvastatin is competitive with respect to the substrate HMG-CoA , and noncompetitive with respect to co-substrate NADPH ...

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In vertebrates, membrane-bound HMG-CoA reductase is the rate-limiting enzyme in the biosynthesis of cholesterol and other isoprenoids. In plants, mevalonate is ...

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